Chlorotrimethylsilane → HCID 58513578, compound

Participants

Reaction Steps

To a solution of tert-butyl 3-(1-(2-(dimethylamino)ethyl)-2-neopentyl-1H-benzo[d]imidazol-5-ylsulfonyl)azetidine-1-carboxylate (prepared in STEP F of Example 1, 327 mg, 0.683 mmol) in methanol (4 mL) was added chlorotrimethylsilane (873 microL, 6.80 mmol). After stirring for 20 h at room temperature, the mixture was concentrated in vacuo. The residue was diluted with methanol (10 mL) and filtered through SCX column. The column was washed with 1 mol/L ammonia in methanol solution to wash out the product. The filtrated was concentrated to give the title compound (270 mg, 97%) as an oil.

Provenance & Evidence