HCID 54434818, compound → HCID 22632125, compound

HRID 2416712Notes

Reaction equation

HRID 2416712 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:29]=[CH:28][C:16]3[CH2:17][CH:18]([CH2:23][C:24]([O:26]C)=[O:25])[C:19](=[O:22])[NH:20][CH2:21][C:15]=3[CH:14]=2)[CH:3]=1.N1C=CC=CC=1NCCCOC1C=CC2CC(CC(OCC)=O)C(=O)NCC=2C=1>O>[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[CH:29]=[CH:28][C:16]3[CH2:17][CH:18]([CH2:23][C:24]([OH:26])=[O:25])[C:19](=[O:22])[NH:20][CH2:21][C:15]=3[CH:14]=2)[CH:3]=1

Participants

4

Reactant 2

HCID 54434818HCID 54434818, compoundHCID 76476612HCID 76476612, compound

Product 1

HCID 22632125HCID 22632125, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

According to the procedure of Example 1(c), except substituting methyl (±)-8-[3-[(4-amino-2-pyridyl)amino]-1-propyloxy]-3-oxo-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate for the ethyl (±)-8-[3-(2-pyridylamino)-1-propyloxy]-3-oxo-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate, the title compound was prepared as a white solid: MS (ES) m/e 385.4 (M+H)+. Anal. Calcd for C20H24N4O4.1.25 H2O: C, 59.03; H, 6.56; N, 13.76. Found: C, 58.80; H, 6.49; N, 13.62.

Sources & evidence

ORD record
ord-dca5fecdd2454dc7acbe4fcabd282e55
Source dataset
uspto-grants-2004_11
Patent number
US06825188B2

Reaction notes

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