Lithium hydroxide, monohydrate → HCID 22632219, compound

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Reaction Steps

A mixture of methyl (±)-8-[3-(pyrimidin-2-ylamino)-1-propyloxy]-3-oxo-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate (0.071 g, 0:18 mmol) and lithium hydroxide monohydrate (0.009 g, 2 mmol) in THF (5 mL) and H2O (2 mL) was stirred at room temperature for 18 hr, then was concentrated. The residue was dissolved in H2O and the pH was adjusted to 4 with 3 N HCl. The resulting solid was collected by filtration and dried to give the title compound (0.05 g, 73%) as a white solid: MS m/e 371.4 (M+H)+. Anal. Calcd for C19H22N4O4.0.5 H2O: C, 60.15; H, 6.11; N, 14.77. Found: C, 60.14; H, 6.06; N, 14.71.

Provenance & Evidence