Hydrochloric Acid → HCID 17939473, compound

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Reaction Steps

(±)-3-Oxo-8-[3-[N-(pyridin-2-yl)-N-(tert-butoxycarbonyl)amino]-1-propyloxy]-2-(4-trifluoromethylbenzyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetic acid (0.158 g, 0.25 mmol) was treated with 4 M HCl in dioxane (3 mL) at RT for 1 h, then the solution was concentrated. ODS chromatography (gradient 5-60% CH3CN/H2O containing 0.1% TFA over 1 h), concentration and lyophilization gave the title compound (0.117 g, 82%): MS (ES) m/e 528.4 (M+H)+. Anal. Calcd for C28H28N3O4.1 CF3CO2H.1.5 H2O: C, 53.89; H, 4.82; N. 6.28. Found: C, 53.55; H, 4.55; N, 6.04.

Provenance & Evidence