HCID 22632206, compound → HCID 22632149, compound

Participants

Reaction Steps

According to the procedure of Example 1(c) except substituting methyl(±)-3-oxo-8-[3-[N-(pyridin-2-yl)-N-(benzoyl)amino]-1-propyloxy]-2-(4-trifluoromethylbenzyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate, for the ethyl (±)-8-[3-(2-pyridylamino)-1-propyloxy]-3-oxo-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate, the crude title compound was prepared. Purification by ODS chromatography (10-80% CH3CN/H2O containing 0.1% TFA over 1 h), concentration and lyophilization gave the title compound (0.025 g, 10%): MS (ES) m/e 632.4 (M+H)+. Anal. Calcd for C35H32 F3N3O5.0.85 CF3CO2H: C, 60.50; H, 4.54; N, 5.74. Found: C, 60.22; H, 4.35; N, 5.77.

Provenance & Evidence