Hydrochloric Acid → HCID 86588610, compound

Participants

Reaction Steps

A Parr hydrogenation apparatus was charged with methyl (S)-3-oxo-8-[3-(pyrimidin-2-ylamino)-1-propyloxy]-2-[4-(trifluoromethyl)benzyl]-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate (42 mg, 0.08 mmol), glacial acetic acid (2 mL), concentrated HCl (0.2 mL), and 10% Pd/C (10 mg). The mixture was shaken under hydrogen (40 psi) for 5 h, then the hydrogen was vented and the catalyst was removed by filtration through celite®. Evaporation of the solvents gave the crude title compound (52 mg) as a dark residue. This was used without further purification. MS (ES) m/e 547.2 (M+H)+.

Provenance & Evidence