Trifluoroacetic acid water → HCID 22632140, compound

HRID 2416740Notes

Reaction equation

HRID 2416740 reaction equation
[O:1]=[C:2]1[C@H:8]([CH2:9][C:10]([O:12]C)=[O:11])[CH2:7][C:6]2[CH:14]=[CH:15][C:16]([O:18][CH2:19][CH2:20][CH2:21][N:22]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)[C:23](OC(C)(C)C)=O)=[CH:17][C:5]=2[CH2:4][N:3]1[CH2:36][C:37]1[CH:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][CH:38]=1.O=C1C(CC(OC)=O)CC2C=CC(OCCCN(C3C=CC=CN=3)C)=CC=2CN1CC1C=CC(C(F)(F)F)=CC=1.N1C=CC=CC=1NCCCOC1C=CC2CC(CC(OC)=O)C(=O)N(C)CC=2C=1.C(C(O)=O)(F)(F)F.O>>[O:1]=[C:2]1[CH:8]([CH2:9][C:10]([OH:12])=[O:11])[CH2:7][C:6]2[CH:14]=[CH:15][C:16]([O:18][CH2:19][CH2:20][CH2:21][N:22]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][N:31]=3)[CH3:23])=[CH:17][C:5]=2[CH2:4][N:3]1[CH2:36][C:37]1[CH:38]=[CH:39][C:40]([C:43]([F:46])([F:44])[F:45])=[CH:41][CH:42]=1

Participants

5

Reactant 4

HCID 22392675Trifluoroacetic acid waterHCID 22632124HCID 22632124, compoundHCID 22632146HCID 22632146, compoundHCID 86591934HCID 86591934, compound

Product 1

HCID 22632140HCID 22632140, compoundYield 15%

Procedure

According to the procedure of Example 4 (c), except substituting methyl(±)-3-oxo-8-[3-(N-(pyridin-2-yl)-N-(methyl)amino)-1-propyloxy]-2-(4-trifluoromethylbenzyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate for the methyl(±)-8-[3-(2-pyridylamino)-1-propyloxy]-2-methyl-3-oxo-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetate, the title compound (0.02 g, 15%) was prepared: MS (ES) m/e 542.1 (M+H)+. Anal. Calcd for C29H30N3O4F3.CF3CO2H.H2O: C, 55.28; H, 4.94; N, 6.24. Found: C, 55.45; H, 4.68; N, 6.14.

Sources & evidence

ORD record
ord-403a5ef0b9a6425a9976ee31b0fb29dc
Source dataset
uspto-grants-2004_11
Patent number
US06825188B2

Reaction notes

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