HCID 22632884, compound → HCID 9820196, compound

HRID 2416882Notes

Reaction equation

HRID 2416882 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:23])=[C:15]([N:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[CH:16]=3)[C:11](=[O:24])[N:10]([O:25]CC3C=CC=CC=3)[C:9]2=[O:33])=[CH:4][CH:3]=1>[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:23])=[C:15]([N:18]4[CH2:22][CH2:21][CH2:20][CH2:19]4)[CH:16]=3)[C:11](=[O:24])[N:10]([OH:25])[C:9]2=[O:33])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 22632884HCID 22632884, compound

Product 1

HCID 9820196HCID 9820196, compoundYield 77.3%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Using the General Method 6A, the reaction of 10% Pd/C (0.027 g) with 1-(4-fluorophenyl)-6-fluoro-3-benzyloxy-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dione (Example L-1, 0.08 g, 0.18 mmol) afforded 0.05 g of the title compound as a solid, mp 183-185° C.

Sources & evidence

ORD record
ord-1cdecc3ac6c64ef3ae4dbc531500007d
Source dataset
uspto-grants-2004_11
Patent number
US06825199B2

Reaction notes

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