HCID 22633011, compound → HCID 22632936, compound

HRID 2416892Notes

Reaction equation

HRID 2416892 reaction equation
FC1C=CC=CC=1N[N:9]1[C:18]2[C:13](=[C:14]([N:20]3[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]3)[C:15]([F:19])=[CH:16][CH:17]=2)[C:12](=[O:27])[N:11]([O:28]CC2C=CC=CC=2)[C:10]1=[O:36]>[Pd]>[F:19][C:15]1[CH:16]=[CH:17][CH:18]=[CH:13][C:14]=1[N:9]1[C:18]2[C:17](=[CH:16][C:15]([F:19])=[C:14]([N:20]3[CH2:21][CH2:22][N:23]([CH3:26])[CH2:24][CH2:25]3)[CH:13]=2)[C:12](=[O:27])[N:11]([OH:28])[C:10]1=[O:36]

Participants

3

Reactant 1

HCID 22633011HCID 22633011, compound

Product 1

HCID 22632936HCID 22632936, compoundYield 200.3%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Using the General Method 6A, the reaction of 10% Pd/C (0.03 g) with 1-(2-fluorophenylamino)-6-fluoro-3-benzyloxy-(4-methylpiperazin-1-yl)-1H-quinazoline-2,4-dione (Example X-1, 0.09 g, 0.18 mmol) provided 0.07 g of the title compound as a solid, mp 160-162° C.

Sources & evidence

ORD record
ord-b5c7667e7fcd476ba5f54fcf366a92d9
Source dataset
uspto-grants-2004_11
Patent number
US06825199B2

Reaction notes

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