HCID 22633007, compound → HCID 22633015, compound

HRID 2416898Notes

Reaction equation

HRID 2416898 reaction equation
C([O:8][N:9]1[C:14](=[O:15])[C:13]2[CH:16]=[C:17]([F:27])[C:18]([N:20]3[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]3)=[N:19][C:12]=2[N:11]([CH2:28][CH3:29])[C:10]1=[O:30])C1C=CC=CC=1>CO.[Pd]>[CH2:28]([N:11]1[C:12]2[N:19]=[C:18]([N:20]3[CH2:25][CH2:24][N:23]([CH3:26])[CH2:22][CH2:21]3)[C:17]([F:27])=[CH:16][C:13]=2[C:14](=[O:15])[N:9]([OH:8])[C:10]1=[O:30])[CH3:29]

Participants

4

Reactant 1

HCID 22633007HCID 22633007, compound

Product 1

HCID 22633015HCID 22633015, compoundYield 72.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Following the procedure of Example 32, hydrogenation of 3-benzyloxy-1-ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-1H-pyrido[2,3-d]pyrimidine-2,4-dione (Example Y-2, 187 mg, 0.450 mmol) and 10% Pd/C (35 mg) in MeOH (5 mL) afforded 105 mg of the title compound as a solid, mp 219-220° C. (decomp.).

Sources & evidence

ORD record
ord-20feb9514a4b48fdbd0eeb8b6ddf5d11
Source dataset
uspto-grants-2004_11
Patent number
US06825199B2

Reaction notes

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