Phenylsilane → HCID 22633023, compound

HRID 2416904Notes

Reaction equation

HRID 2416904 reaction equation
C1([SiH3])C=CC=CC=1.C([O:11][N:12]1[C:21](=[O:22])[C:20]2[C:15](=[CH:16][C:17]([N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)=[C:18]([F:23])[CH:19]=2)[N:14]([CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:13]1=[O:36])C=C>ClCCl>[CH2:29]([N:14]1[C:15]2[C:20](=[CH:19][C:18]([F:23])=[C:17]([N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)[CH:16]=2)[C:21](=[O:22])[N:12]([OH:11])[C:13]1=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

4

Reactant 2

HCID 12752PhenylsilaneHCID 22632920HCID 22632920, compound

Product 1

HCID 22633023HCID 22633023, compoundYield 42.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Phenylsilane (0.07 mL, 0.56 mmol) and palladium tetrakistriphenylphosphine (17 mg, 0.015 mmol) were added to a solution of 3-allyloxy-1-benzyl-6-fluoro-7-pyrrolidin-1-yl-1H-quinazoline-2,4-dione (Example B-4, 0.15 g, 0.4 mmol) in 10 mL of dichloromethane at 0° C. The mixture was stirred for 17 hours and filtered to give 0.06 g of the title compound as a solid, mp 234-236° C.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-e99f5521fb684e6d91920cbd7ade18ba
Source dataset
uspto-grants-2004_11
Patent number
US06825199B2

Reaction notes

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