2-Thiophenecarbonyl chloride → HCID 10228566, compound

Participants

Reaction Steps

To a stirred solution of the above amino benzimidazole (0.7 g, 1.8 mmol) in pyridine (10 mL) was added 2-thiophenecarbonyl chloride (0.41 mL, 3.8 mmol). The reaction was complete in 6 h. The pyridine was evaporated and the resulting orange solid was purified by flash chromatography with 1% MeOH/dichloromethane to give the title compound (0.61 g, 67%), m.p. 82-84° C.

Provenance & Evidence