2-Thiophenecarbonyl chloride → HCID 10166146, compound

Participants

Reaction Steps

To a stirred solution of the above amino benzimidazole (0.7 g, 2.1 mmol) in pyridine (10 mL) was added 2-thiophenecarbonyl chloride (0.68 mL, 6.4 mmol). The reaction was complete in 6 h. The pyridine was evaporated and the resulting orange solid was purified by flash chromatography with 1% MeOH/dichloromethane to give thiophene-2-carboxylic acid 3-{5-(cyclohexyl-methyl-carbamoyl)-2-[(thiophene-2-carbonyl)-amino]-benzoimidazol-1-yl}-propyl ester (0.50 g, 43%), m.p. 92-94° C.

Provenance & Evidence