Acetic Anhydride → HCID 59083091, compound

Participants

Reaction Steps

To a solution of 1-(3-hydroxy-propyl)-2-[(thiophene-2-carbonyl)-amino]-1H-benzoimidazole-5-carboxylic acid cyclohexyl-methyl-amide (Example 4) (0.07 g, 0.16 mmol) in THF (10 mL) was added acetic anhydride (0.02 mL, 0.19 mmol), followed by triethylamine (0.02 mL, 0.17 mmol), and the mixture was stirred at room temperature for 48 h. The resulting solution was washed with 1M HCl (10 mL) and the organic layer was dried over magnesium sulfate. The solvent was evaporated and the resulting oil was purified by flash chromatography with 5% MeOH/dichloromethane to give the title compound (0.05 g, 65%), m.p. 74-76° C.

Provenance & Evidence