Bromotrimethylsilane → HCID 22630513, compound

Participants

Reaction Steps

To a solution of 7.03 g of 1-(diethylphosphono)-8-(nonafluorobutyl)octane in 30 mL of dichloromethane was added 6.12 g of bromotrimethylsilane. After 18 hr at room temperature, the solution was concentrated to a pale yellow liquid, and the intermediate silylphosphonate ester was dissolved in 150 mL of methanol. The resultant solution was stirred at room temperature for 30 min and concentrated to a white solid. Dissolution in methanol and concentration were repeated two times, and two recrystallizations of the crude product from acetonitrile gave 4.68 g of 1-phosphono-8-(nonafluorobutyl)octane (CF3(CF2)3(CH2)8PO3H2) as white crystals, m.p. 87-89° C.

Provenance & Evidence