HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Cyanide → Ethyl 4-(cyanomethyl)-1H-pyrrole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | [5-(Ethoxycarbonyl)-1H-pyrrol-3-yl]-N,N,N-trimethyl-methanaminium iodide | HCID 86662429 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 4-(cyanomethyl)-1H-pyrrole-2-carboxylate | HCID 66636709 | — |
Reaction Steps
A solution of the product obtained in Step E and sodium cyanide (0.225 g) in ethanol is heated at reflux for 72 hours. After evaporation to dryness, the residue is taken up in a mixture of CH2Cl2/water. The aqueous phase is extracted three times with CH2Cl2. The organic phases are combined. The organic phase is dried over magnesium sulphate, filtered and evaporated to dryness to yield the title product which is used directly in the next Step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08653073B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-dc555aa76ab04acf8ca88d501acdb85b |
| Source note | uspto-grants-2014_02 |