HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 9877694, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Acetamide, N-(2-methyl-4-quinolinyl)- | HCID 594177 | — |
| Product | HCID 9877694 | HCID 9877694 | 78.6% |
Reaction Steps
Reaction of N-(2-methyl-quinolin-4-yl)acetamide (136 mg, 0.679 mmol) using the general procedure for small scale hydrogenations (workup with NaOH in place of saturated NaHCO3) provided N-(2-methyl-5,6,7,8-tetrahydroquinolin-4-yl) acetamide (109 mg, 78%): 1H NMR δ 1.83-1.90 (m, 4H), 2.21 (s, 3H), 2.47 (s, 3H), 2.46-2.2.53 (m, 2H), 2.84-2.87 (m, 2H), 7.18 (br s, 1H), 7.82 (br s, 1H); 13C NMR δ 22.7,22.8,23.5,24.6,25.3, 33.1, 112.3,117.3, 143.7, 156.4, 157.3, 169.0; MS m/z: 205 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06825351B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-39a4630ef5d447329e36a5393f68812a |
| Source note | uspto-grants-2004_11 |