HCID 21087446, compound → HCID 21087444, compound

Participants

Reaction Steps

Ethanol (30 ml) solution of 3-(R)-[1-(tert-butoxycarbonyl)amino-1-cyclobutyl]methyl-1-[1-(R)-phenylethyl]pyrrolidine (isomer B1) (516 mg, 1.44 mmol) was mixed with 10% palladium-carbon catalyst (53.8% moisture, 500 mg), and 5 hours of catalytic hydrogenation was carried out in an atmosphere of hydrogen at an outer temperature of 50° C. under atmospheric pressure. The reaction solution was filtered and the solvent was evaporated under a reduced pressure to obtain 366 mg (quantitative) of the title compound as colorless crystals.

Provenance & Evidence