Tyrosol → HCID 22633982, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-hydroxyphenethyl alcohol (5.02 g, 36.3 mmol) and chloroethyl piperidine (7.36 g, 39.96 mmol) in 30 ml of DMF, 5 g of K2CO3 was added. The reaction was stirred at 80° C. overnight. After cooling the mixture was quenched with water then extracted in CHCl3. The organic layer was separated, dried over Na2SO4, filtered and concentrated. 2-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-ethanol (4.58 g, 18.4 mmol) was isolated as a brown oil; Yield 51%; MS: 250.3 (M+H)+

Provenance & Evidence