6-Bromohexanenitrile → HCID 22634020, compound

HRID 2417263Notes

Reaction equation

HRID 2417263 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[CH2:5][S:6]([C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][C:17]#[C:18][CH3:19])=[CH:11][CH:10]=1)(=[O:8])=[O:7])[CH3:2].Br[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]#[N:28]>>[CH2:16]([O:15][C:12]1[CH:11]=[CH:10][C:9]([S:6]([CH:5]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]#[N:28])[C:4]([O:3][CH2:1][CH3:2])=[O:20])(=[O:7])=[O:8])=[CH:14][CH:13]=1)[C:17]#[C:18][CH3:19]

Participants

3

Reactant 2

HCID 810936-BromohexanenitrileHCID 11335441Ethyl{[4-(2-butynyloxy)phenyl]sulfonyl}acetate

Product 1

HCID 22634020HCID 22634020, compoundYield 60%

Procedure

Ethyl 2-{[4-(2-butynyloxy)phenyl]sulfonyl}-7-cyanoheptanoate was prepared according to the general method as outlined in example 1 (step 4), starting from (4-but-2-ynyloxy-benzenesulfonyl)-acetic acid ethyl ester (10 g, 33.8 mmol) and 6-bromohexanenitrile (4.48 ml, 33.8 mmol); 7.9 g white solid. mp 63° C.; Yield 60%; MS (EI): 391.4 (M+H)+

Sources & evidence

ORD record
ord-437b6284fb6643ae8215dc80e8375c9d
Source dataset
uspto-grants-2004_11
Patent number
US06825354B2

Reaction notes

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