2-Butyn-1-ol → HCID 86757738, compound

HRID 2417277Notes

Reaction equation

HRID 2417277 reaction equation
[CH2:1]([O:3][C:4](=[O:25])[CH:5]([S:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=1)[C:6]1[CH:11]=[CH:10][C:9]([C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[CH:8][CH:7]=1)[CH3:2].[CH2:26](O)[C:27]#[C:28][CH3:29]>>[CH2:1]([O:3][C:4](=[O:25])[CH:5]([S:17][C:18]1[CH:19]=[CH:20][C:21]([O:24][CH2:26][C:27]#[C:28][CH3:29])=[CH:22][CH:23]=1)[C:6]1[CH:7]=[CH:8][C:9]([C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[CH:10][CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 129912-Butyn-1-olHCID 86757739HCID 86757739, compound

Product 1

HCID 86757738HCID 86757738, compoundYield 74%

Procedure

Ethyl{[4-(2-butynyloxy)phenyl]sulfanyl}[4-(2-thienyl)phenyl]acetate was prepared according to the general method as outlined in example 83 (step 2), starting from ethyl[(4-hydroxyphenyl)sulfanyl][4-(2-thienyl)phenyl]acetate (1.6 g, 4.3 mmol) and 2-butyn-1-ol (0.33 ml, 4.32 mmol); 1.34 g yellow oil. Yield 74%; MS(EI): 421.71 (M+H)+

Sources & evidence

ORD record
ord-002960d155a14cd2b78ca95935b02d71
Source dataset
uspto-grants-2004_11
Patent number
US06825354B2

Reaction notes

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