HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 22633852, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 1,6-Hexanediol | HCID 12374 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | Azide | HCID 33558 | — |
| Reactant | Lithium azide | HCID 88163 | — |
| Reactant | tert-Butyldiphenylchlorosilane | HCID 94078 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22633852 | HCID 22633852 | — |
Reaction Steps
1,6-Hexanediol is monosilylated with tert-butylchloro-diphenylsilane (1 equivalent) in dry pyridine. It is then mesylated with mesyl chloride in pyridine and subsequently treated with lithium azide in DMF solvent. The resulting azide derivative is reduced with triphenyl phosphine to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06825331B2 |
| Source dataset | uspto-grants-2004_11 |
| ORD ID | ord-30b0a78b3c134b06bc281efc39f18039 |
| Source note | uspto-grants-2004_11 |