Sulfuric Acid → 2-Chloro-1,3,5-trimethylbenzene

Participants

Reaction Conditions

Reaction Steps

Mesitylene (1 mmol) was treated with sodium chloride (1.2 mmol) in acetonitrile: water (2:1, 6 ml). 20% Sulfuric acid (5 ml) and sodium periodate (20 mol %) was added to the reaction mixture. The mixture was heated at 80° C. under inert atmosphere for 6 h. The product was purified by column chromatography to give chloromesitylene (40%).

Provenance & Evidence