Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Acetophenone | HCID 7410 | — |
| Reactant | Sodium periodate | HCID 23667635 | — |
| Solvent | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Product | 2-Chloroacetophenone | HCID 10757 | 55% |
Reaction Steps
Acetophenone (1 mmol) was treated with sodium chloride (1.2 mmol) in acetonitrile: water (2:1, 6 ml). 20% Sulfuric acid (5 ml) and sodium periodate (20 mol %) was added to the reaction mixture. The mixture was heated at 80° C. under inert atmosphere for 6 h. The product was purified by column chromatography to give α-chloroacetophenone (55%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06825383B1 |
|---|
| Source dataset | uspto-grants-2004_11 |
|---|
| ORD ID | ord-09ea553385964a57adb5ddcc860ce663 |
|---|
| Source note | uspto-grants-2004_11 |
|---|
