Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Styrene | HCID 7501 | — |
| Reactant | Sodium periodate | HCID 23667635 | — |
| Solvent | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Product | 2-Chloro-1-phenylethanol | HCID 92898 | 95% |
Reaction Steps
Styrene (1 mmol) was treated with sodium chloride (1.2 mmol) in acetonitrile: water (2:1, 6 ml). 20% Sulfuric acid (5 ml) and sodium periodate (20 mol %) was added to the reaction mixture. The mixture was heated at 70° C. under inert atmosphere for 18 h. The product was purified by column chromatography to give 1-phenyl-2-chloroethanol (95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06825383B1 |
|---|
| Source dataset | uspto-grants-2004_11 |
|---|
| ORD ID | ord-8fe7ac3156164f4da33140b768551537 |
|---|
| Source note | uspto-grants-2004_11 |
|---|
