HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2417383Generated: November 4, 2026
Indene → 6-(5-Hydroxy-4'-isopropyl-4-methoxy-biphenyl-2-yl)-5,6a,7,11b-tetrahydro-6h-indeno[2,1-c]quinoline-2-carboxamidine
https://huagongshe.com/reaction/2417383
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Indene | HCID 7219 | — |
| Reactant | Benzenecarboximidamide, 4-amino-, hydrochloride (1:1) | HCID 122765 | — |
| Reactant | Indium(III) trifluoromethanesulfonate | HCID 2734680 | — |
| Reactant | HCID 22633322 | HCID 22633322 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 6-(5-Hydroxy-4'-isopropyl-4-methoxy-biphenyl-2-yl)-5,6a,7,11b-tetrahydro-6h-indeno[2,1-c]quinoline-2-carboxamidine | HCID 22633219 | — |
Reaction Steps
4-amino-benzamidine mono HCl salt (34.5 mg, 0.2 mmole) was suspended in acetonitrile (1 mL). The suspension was treated with 5-Hydroxy-4′-isopropyl-4-methoxy-biphenyl-2-carbaldehyde (27.0 mg, 0.1 mmole) and indene(23.2 mg, 0.2 mmole). Indium triflate (11.2 mg, 0.02 mmole) was added and the reaction was heated at 70° C. for 24 hours. The desired product was purified using reverse phase HPLC. Mass spectrum: 504 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06825208B2 |
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| Source dataset | uspto-grants-2004_11 |
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| ORD ID | ord-822ec93ebb484fc1b13aca28310742bc |
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| Source note | uspto-grants-2004_11 |
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