2-Ethoxycarbonylphenylboronic acid → HCID 86590421, compound

HRID 2417386Notes

Reaction equation

HRID 2417386 reaction equation
C([O:4][C:5]1[C:12]([O:13][CH3:14])=[CH:11][C:8]([CH:9]=[O:10])=[C:7](Br)[C:6]=1[O:16][CH3:17])(=O)C.[CH2:18]([O:20][C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1B(O)O)=[O:22])[CH3:19]>>[CH2:18]([O:20][C:21]([C:23]1[C:24]([C:7]2[C:8]([CH:9]=[O:10])=[CH:11][C:12]([O:13][CH3:14])=[C:5]([OH:4])[C:6]=2[O:16][CH3:17])=[CH:25][CH:26]=[CH:27][CH:28]=1)=[O:22])[CH3:19]

Participants

3

Reactant 2

HCID 27734052-Ethoxycarbonylphenylboronic acidHCID 22633147HCID 22633147, compound

Product 1

HCID 86590421HCID 86590421, compound

Procedure

6′-Formyl-3′-hydroxy-2′,4′-dimethoxy-biphenyl-2-carboxylic acid ethyl ester was prepared from 4-acetoxy-2-bromo-3,5-dimethoxybenzaldehyde (Example 162, step a) and 2-ethoxycarbonylphenyl boronic acid using the protocol described in Example 147, step a. Mass Spectrum: 331 (M+1).

Sources & evidence

ORD record
ord-9452d24b5181449da178dc8705951489
Source dataset
uspto-grants-2004_11
Patent number
US06825208B2

Reaction notes

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