Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Indene | HCID 7219 | — |
| Reactant | tert-butyl N-[(4-aminophenyl)methyl]carbamate | HCID 2756041 | — |
| Reactant | HCID 22633138 | HCID 22633138 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 22633132 | HCID 22633132 | — |
Reaction Steps
To a suspension of 5′-Benzyloxy-2′-formyl-2,4′-dimethoxy-biphenyl-4-carboxylic acid (50 mg, 0.127 mmol) and (4-Amino-benzyl)-carbamic acid tert-butyl ester (28 mg, 0.127 mmole) in 2 ml dry acetonitrile was added 30μl of indene and a catalytic amount of In(OTf)3. The reaction was sealed and heated at 75° C. for 16 h. The reaction was then allowed to cool to room temperature and then purified by HPLC. Mass spectrum 505 (M−17); in the presence of 0.1M ammonium acetate 521 (M−1) observed for negative ion mode.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06825208B2 |
|---|
| Source dataset | uspto-grants-2004_11 |
|---|
| ORD ID | ord-7e7637e617ca43c185d551af2e5d7492 |
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| Source note | uspto-grants-2004_11 |
|---|
