HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 241740Generated: October 27, 2026
Sodium hydride → 5-(4-Chlorophenyl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one
https://huagongshe.com/reaction/241740
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Ethyl N'-[1-(4-chloro-phenyl)-2-hydroxy-ethylidene]-hydrazinecarboxylate | HCID 86662431 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(4-Chlorophenyl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one | HCID 13365915 | — |
Reaction Steps
Sodium hydride (60% in oil, 16 mmoles) is added, in small portions and at ambient temperature, to a solution of the compound obtained in Step B (100.5 mmoles) in ethanol (800 ml). After reacting for 2 hours, the reaction mixture is cooled to 0° C. and stiffing is continued for 30 minutes. The precipitate formed is filtered off, washed with cold ethanol and then dried in vacuo to yield the title product, which is used directly in the next Step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08653073B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-2b7b449cd0a94fb88bc5f0d70a3b0284 |
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| Source note | uspto-grants-2014_02 |
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