Sodium Hydroxide → HCID 69817975, compound

Participants

Reaction Steps

To a solution of ethyl 3-[[[[4-[(2S)-3-hydroxy-2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]propyl]phenyl]-amino]carbonyl]amino]benzoate (148 mg) in ethanol (2.0 ml) was added 1N sodium hydroxide solution (292 μl) and the solution was refluxed for 4 hours. An additional portion of 1N sodium hydroxide solution (58.3 μl) was added and the whole was refluxed for 3 hours. After cooling to room temperature, the solvent was removed by evaporation to give sodium 3-[[[[4-[(2S)-3-hydroxy-2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]propyl]phenyl]amino]carbonyl]amino)-benzoate (158 mg) as a white solid.

Provenance & Evidence