HCID 86591188, compound → HCID 69817908, compound

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Reaction Steps

tert-Butyl N-[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]-N-[(1S)-2-hydroxy-1-(4-[[(1-methyl-1H-indol-5-yl)carbonyl]amino]benzyl]ethyl]carbamate (101 mg) was dissolved in 4N hydrogen chloride in ethanol (1.0 ml) and the solution was stirred at room temperature for 5 hours. The solvent was removed by evaporation and the residual solid was dissolved in methanol. To the solution was added 1N sodium hydroxide solution (175 μl) and the solvent was removed by evaporation. The residue was chromatographed on silica gel (eluent: chloroform/methanol=9/1) to give N-[4-[(2S)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-hydroxypropyl]phenyl]-1-methyl-1H-indole-5-carboxamide (34.2 mg) as a pale yellow solid.

Provenance & Evidence