HCID 69818043, compound → HCID 69818012, compound

Participants

Reaction Steps

In 4N hydrogen chloride in ethanol (2.0 ml), tert-butyl N-[(2S)-2-hydroxy-3-phenoxypropyl]-N-[(1S)-2-hydroxy-1-[4-[(1H-pyrrol-3-ylcarbonyl)amino]benzyl]ethyl]carbamate (113.5 mg) was dissolved and the solution was stirred at room temperature for 30 hours. After concentration under reduced pressure, the residue was extracted with ethyl acetate (20 ml) and washed with saturated sodium hydrogencarbonate aqueous solution (20 ml). The organic layer was separated and the aqueous layer was extracted twice with ethyl acetate (20 ml). The organic layers were combined and washed with brine, and dried over magnesium sulfate to give N-[4-[(2S)-3-hydroxy-2-[[(2S)-2-hydroxy-3-phenoxypropyl]amino]propyl]-phenyl]-1H-pyrrole-3-carboxamide (18.2 mg) as a yellow solid.

Provenance & Evidence