HCID 22632548, compound → HCID 22632393, compound

HRID 2417486Notes

Reaction equation

HRID 2417486 reaction equation
[Cl:1][C:2]1[CH:41]=[CH:40][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][C:17]([CH2:19][CH2:20][C:21]([O:23]C)=[O:22])=[CH:18][C:12]=3[N:11]([CH2:25][C:26]3[CH:31]=[CH:30][C:29]([C:32]([N:34]4[CH2:38][CH2:37][CH2:36][CH2:35]4)=[O:33])=[CH:28][CH:27]=3)[C:10](=[O:39])[CH2:9]2)=[O:7])=[CH:4][CH:3]=1>[OH-].[Na+].C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][C:17]([CH2:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:18][C:12]=3[N:11]([CH2:25][C:26]3[CH:31]=[CH:30][C:29]([C:32]([N:34]4[CH2:38][CH2:37][CH2:36][CH2:35]4)=[O:33])=[CH:28][CH:27]=3)[C:10](=[O:39])[CH2:9]2)=[O:7])=[CH:40][CH:41]=1

Participants

4

Reactant 1

HCID 22632548HCID 22632548, compound

Product 1

HCID 22632393HCID 22632393, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

10 mg (0.017 mmol) of methyl 3-[4-(4-chlorobenzoyl)-2-oxo-1-(4-(1-pyrrolidinecarbonyl)benzyl)-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-8-yl]propionate was dissolved in a mixture of 5 ml of 1 N sodium hydroxide and 5 ml of ethanol. The obtained solution was stirred at room temperature for 5 hours. The solvent was evaporated, and the obtained crude product was treated in the same manner as in step 3 in Example 1 to obtain the title compound.

Workup

  1. customThe solvent was evaporated
  2. customthe obtained crude product
  3. additionwas treated in the same manner as in step 3 in Example 1

Sources & evidence

ORD record
ord-a0663bbccb294e9c828330633935f48d
Source dataset
uspto-grants-2004_11
Patent number
US06825191B2

Reaction notes

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