Triethylamine → HCID 22632676, compound

Participants

Reaction Steps

450 mg (0.87 mmol) of 8-hydroxymethyl-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)benzyl]-4-(4-chlorobenzoyl)-1,3,4,5-tetrahydrobenzo[e][1,4]diazepin-2-on was dissolved in 5 ml of dichloromethane. 0.18 ml (1.31 mmol) of triethylamine and 0.08 1 ml (1.05 mmol) of methanesulfonyl chloride were added to the obtained solution under cooling with ice, and the obtained mixture was stirred for 2 hours. After the treatment with dichloromethane as the extracting solvent by an ordinary method, the crude product was obtained.

Provenance & Evidence