Acetyl chloride → 5-(2-Chloroacetyl)-6-fluoroindolin-2-one

HRID 241751Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 241751
[Cl-:1].[Al+3].[Cl-].[Cl-].[F:5][C:6]1[CH:14]=[C:13]2[C:9]([CH2:10][C:11](=[O:15])[NH:12]2)=[CH:8][CH:7]=1.[C:16](Cl)(=[O:18])[CH3:17]>C(Cl)Cl>[Cl:1][CH2:17][C:16]([C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][C:6]=1[F:5])[NH:12][C:11](=[O:15])[CH2:10]2)=[O:18]

Komponenten

5

Edukt 3

HCID 6367Acetyl chlorideHCID 37310136-fluoro-2,3-dihydro-1H-indol-2-oneHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 106093595-(2-Chloroacetyl)-6-fluoroindolin-2-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

20 mL of DCM are added dropwise under nitrogen to aluminium chloride (31.1 mmol) at 0-5° C. 6-Fluoroindolin-2-one (5.18 mmol) and acetyl chloride (6.73 mmol) are added to the mixture. The reaction mixture is heated at 50° C. overnight. The reaction mixture is cooled to ambient temperature and then poured into an ice bath, and the suspension obtained is filtered and then washed with cold water to yield the title product.

Aufarbeitung

  1. temperatureThe reaction mixture is cooled to ambient temperature
  2. additionpoured into an ice bath
  3. customthe suspension obtained
  4. filtrationis filtered
  5. washwashed with cold water

Quellen und Nachweise

ORD-Eintrag
ord-d78c29d352cb4bba84c7425fa3357d2b
Quelldatensatz
uspto-grants-2014_02
Patentnummer
US08653073B2

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