反应详情

温度

50 °C

20 mL of DCM are added dropwise under nitrogen to aluminium chloride (31.1 mmol) at 0-5° C. 6-Fluoroindolin-2-one (5.18 mmol) and acetyl chloride (6.73 mmol) are added to the mixture. The reaction mixture is heated at 50° C. overnight. The reaction mixture is cooled to ambient temperature and then poured into an ice bath, and the suspension obtained is filtered and then washed with cold water to yield the title product.

1. temperatureThe reaction mixture is cooled to ambient temperature
2. additionpoured into an ice bath
3. customthe suspension obtained
4. filtrationis filtered
5. washwashed with cold water