Isopropanol → HCID 22632687, compound

Participants

Reaction Steps

22 mg (0.044 mmol) of 4-(4-chlorobenzoyl)-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)benzyl]-8-hydroxy-1,3,4,5-tetrahydrobenzo[e][1,4]-diazepin-2-on was dissolved in 5 ml of THF. 15 mg (0.05 mmol) of triphenylphosphine, 0.004 ml (0.05 mmol) of isopropyl alcohol and 25 mg (0.05 mmol) of diethylazo dicarboxylate were added to the obtained solution, and they were stirred at room temperature overnight. After the treatment with ethyl acetate as the extracting solvent, the obtained crude product was treated in the same manner as in step 3 in Example 1 to obtain the title compound.

Provenance & Evidence