Triethylamine → HCID 22632628, compound

Participants

Reaction Conditions

Reaction Steps

15 mg (0.029 mmol) of 4-(4-chlorobenzoyl)-1-(4-piperidinyl-methyl)-1,3,4,5-tetrahydrobenzo[e][1,4]diazepin-2-on trifluoroacetate was dissolved in 5 ml of ethanol. 120 mg (1.7 mmol) of ethyl acetimidate hydrochloride and 0.50 ml (3.6 mmol) of triethylamine were added to the obtained solution, and they were stirred at 80° C. for 2 days. The solvent was evaporated, and the obtained crude product was treated in the same manner as in Step 3 in Example 1 to obtain the title compound.

Provenance & Evidence