Methyl iodide → HCID 22632614, compound

Participants

Reaction Steps

20 mg (0.034 mmol) of 4-(4-chlorobenzoyl)-1-[4-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)benzyl]-1,3,4,5-tetrahydrobenzo[e][1,4]diazepin2on trifluoroacetate obtained in Example 125 was dissolved in 3 ml of DMF. 3 mg (0.075 mmol) of sodium hydride was added to the obtained solution, and they were stirred at room temperature for 30 minutes. 30 mg (0.21 mmol) of methyl iodide was added to the reaction mixture, and they were stirred at room temperature for 5 hours. The solvent evaporated, and the obtained crude product was treated in the same manner as in step 3 in Example 1 to obtain the title compound.

Provenance & Evidence