Propargyl bromide → HCID 22632670, compound

Participants

Reaction Steps

50 mg (0.17 mmol) of 4-(4-chlorobenzoyl)-1,3,4,5-tetrahydrobenzo[e][1,4]diazepin-2-on was dissolved in 4 ml of DMF. 7 mg (0.18 mmol) of sodium hydride was added, to the obtained solution, and they were stirred at room temperature for 30 minutes. 30 mg (0.25 mmol) of 3-bromopropyne was added to the obtained solution, and they were stirred at room temperature overnight. After the treatment with ethyl acetate as the extracting solvent by an ordinary method, the obtained crude product was purified by the silica gel column chromatography.

Provenance & Evidence