反应详情

16.6 g (0.12 mole) of potassium carbonate and 24 g (0.105 mole) of butyl-p-toluene sulphonate are added to a solution of 19 g (0.10 mole) of 3-isopropyl-6-chlorouracil in 200 ml of dimethyl formamide. The mixture is heated for 1 hour to 80° C. After evaporation of the solvent, the residue is taken up in water, followed by extraction with CH2Cl2. The extract is dried over Na2SO4 and the solvent is evaporated, leaving 24 g of a pale yellow oily product.

1. temperatureThe mixture is heated for 1 hour to 80° C
2. customAfter evaporation of the solvent
3. extractionfollowed by extraction with CH2Cl2
4. dry with materialThe extract is dried over Na2SO4
5. customthe solvent is evaporated