1-(3-(Trifluoromethyl)phenyl)piperazine → HCID 15592121, compound

Participants

Reaction Steps

A mixture of 1-(3-trifluoromethylphenyl)-piperazine (2.3 g) and 2-methoxy-2,4,6-cycloheptatrien-1-one (2.0 g) in methanol (50 ml) was refluxed for 24 hr and evaporated. The residue was chromatographed on silica gel (100 g) using ethyl acetate. The eluates were evaporated and crystallized from ethyl acetate-benzene to give the title compound (4.08 g): mp 112°-114° C.; ir (CHCl3) 1570 cm-1 ; uv max (MeOH)350 (ε=10575) and 256 nm (ε=31730); nmr (CDCl3)δ 3.5 (m, 8H) and 7.0 (m, 9H); and Anal. Calcd for C18H17F3N2O: C, 64.66% H, 5.12% N, 8.38% and Found: C, 64.84% H, 5.17% N, 8.54%.

Provenance & Evidence