反应详情

Sodium carbonate (18.84 g) and water (41.4 ml) was added to a stirring suspension at 0° to 5° C. of 2-bromo-1-(3,4-dimethoxyphenyl)-1-ethanone (32.03 g, described in Example 4) and 1-benzylpiperazine (24 ml) in acetonitrile (90 ml). The suspension was stirred at room temperature for 2.5 hr and evaporated. The residue was dissolved in a mixture of water and chloroform, and the chloroform layer was dried and evaporated. Chromatographic purification on silica gel (700 g) using ethyl acetate-hexane (60:1 to 100:1) gave 32 g of 2-(4-benzyl-1-piperazinyl)-1-(3,4-dimethoxyphenyl)-1-ethanone, nmr(CDCl3) δ2.65, 3.57, 3.74, 3.89, 3.91, 6.81, 7.37 and 7.53.

1. customevaporated
2. dissolutionThe residue was dissolved in a mixture of water and chloroform
3. dry with materialthe chloroform layer was dried
4. customevaporated
5. customChromatographic purification on silica gel (700 g)