反应详情

温度

60 °C

A mixture of 8.5 g (0.035 moles) of 1-(4-nitrophenyl)-2-nitro-1,3-propanediol, 14 g (0.13 moles) of acetic anhydride and 1 g of acetyl chloride is stirred at 60° C. for 3 hours. The mixture is cooled, poured onto 60 g of ice and stirred thoroughly. Water is decanted, 10 ml of isopropanol are added to the waxy residue, and the substance is crystallized at 0° C. The separated crystalline product is filtered off, washed with isopropanol and dried at 20° C. 8.8 g (77%) of the title compound are obtained; m.p.: 63°-66° C.

1. temperatureThe mixture is cooled
2. stirringstirred thoroughly
3. customWater is decanted
4. addition10 ml of isopropanol are added to the waxy residue
5. customthe substance is crystallized at 0° C
6. filtrationThe separated crystalline product is filtered off
7. washwashed with isopropanol
8. customdried at 20° C