HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanoacetamide → Milrinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanoacetamide | HCID 7898 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Ethoxy-3-(4-pyridyl)-3-buten-2-one | HCID 3021227 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Milrinone | HCID 4197 | — |
Reaction Steps
The process according to claim 4 where 2-ethoxy-1-(4-pyridinyl)ethenyl methyl ketone is reacted with cyanoacetamide in the presence of at least a molar equivalent quantity of sodium hydroxide per mole of cyanoacetamide in methanol and the reaction mixture is neutralized to produce 1,2-dihydro-6-methyl-2-oxo-5-(4-pyridinyl)nicotinonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04469871 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-ca57537861834c5ab7e20e5a6689ba3f |
| Source note | uspto-grants-1984_09 |