Dimethylformamide → HCID 13338435, compound

Participants

Reaction Steps

A mixture of 9.5 g (0.05 mol) of 7-chloro-1,3,5-trimethyl-1H-pyrazolo[4,3-d]pyrimidine (Example 3), 10 g (0.075 mol) of 3-amino-2-butanone, ethylene ketal, and 14 ml of triethylamine in 30 ml of dimethylformamide is stirred at 50°-55° C. for 24 hours. The mixture is evaporated in vacuo, the residue is dissolved in methylene dichloride and washed with ammonium hydroxide solution. The organic layer is dried over MgSO4 and evaporated in vacuo. The residue is crystallized from pet ether to give 12.6 g (87%) of 1,3,5-trimethyl-N-[1-(2-methyl-1,3-dioxolan-2-yl)ethyl]-1H-pyrazol[4,3-d]pyrimidin-7-amine, mp 101°-103° C.

Provenance & Evidence