HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-Benzyl-4-(2-hydroxy-4-methoxybenzoyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | (2-Hydroxy-4-methoxyphenyl)(piperidin-4-yl)methanone | HCID 13076390 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Benzyl-4-(2-hydroxy-4-methoxybenzoyl)piperidine | HCID 13076397 | 57.4% |
Reaction Steps
A mixture of 14.50 g of 4-(2-hydroxy-4-methoxybenzoyl)piperidine, 6.40 ml of benzyl bromide, 10.20 g of sodium bicarbonate and 74.0 ml of dimethylformamide was stirred at 60° for 15 hrs. The reaction mixture was poured into 250 ml of water and a precipitate formed. The precipitate was collected, washed with water and recrystallized from ethanol to yield 10.0 g (57.4%) of product, mp, 123°-125°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04469869 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-eb06d65273ea426d97a92d029cd4408b |
| Source note | uspto-grants-1984_09 |