HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → 5-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | 1-(4-(5-Fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethanone | HCID 13076420 | — |
| Produkt | 5-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole hydrochloride | HCID 2794754 | 83% |
Reaktionsschritte
A mixture of 17.5 g of 3-(1-acetyl-4-piperidyl)-5-fluoro-1,2-benzisoxazole and 110 ml of 6N hydrochloric acid was stirred under reflux for 6 hrs. After standing at ambient temperature for ca 12 hrs, a solid was collected, washed with acetone and dried to yield 14.2 g (83%) of product as the hydrochloride salt, mp 297°-299°.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04469869 |
| Quelldatensatz | uspto-grants-1984_09 |
| ORD ID | ord-44d6372617f74e0084a5ce1d27098782 |
| Quellennotiz | uspto-grants-1984_09 |