反应详情

To a solution of nerolidol (5.3 g, 0.024 mole) in 20 ml of dry ether, n-butyllithium (9.6 ml, 0.024 mole, 2.5M in hexane) was added with stirring under a blanket of dry nitrogen. The reaction mixture was cooled by means of a dry ice-acetone bath. Upon completion of addition, ethyl 2-(2-butyl)malonyl chloride (5.0 g, 0.024 mole) was added slowly. After addition was completed, the mixture was allowed to warm to room temperature with stirring for a period of 4 hours.

1. temperatureThe reaction mixture was cooled by means of a dry ice-acetone bath
2. additionwas added slowly
3. additionAfter addition
4. stirringwith stirring for a period of 4 hours