Adipic Acid → Methyl cyanovalerate

Participants

Reaction Conditions

Reaction Steps

Into a 1-liter, stainless autoclave were introduced 301.2 g of Solution A, 39.4 g (0.270 mole) of adipic acid, 51.8 g (0.298 mole) of dimethyl adipate and 29.2 g (0.270 mole) of adiponitrile. The content of the autoclave was stirred at 230° C. for 2.5 hours. After cooling the reaction mixture, 160.0 g of methanol was added and the resulting mixture was stirred at 200° C. for 2 hours. Then, the liquid reaction mixture was distilled under reduced pressure to obtain 77.5 g (0.550 mole) of methyl cyanovalerate. The yield thereof corresponded to 203.7% based on the adipic acid charged.

Provenance & Evidence