HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 1,4-dithia-7-azaspiro [4.4]nonane-8(S)-carboxylic acid, methyl ester hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | HCID 13373610 | HCID 13373610 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1,4-dithia-7-azaspiro [4.4]nonane-8(S)-carboxylic acid, methyl ester hydrobromide | HCID 13274672 | — |
Reaction Steps
Dissolve 3.0 g of 7-benzyloxycarbonyl-1,4-dithia-7-azaspiro[4.4]nonane-8(S)-carboxylic acid methyl ester (3.0 g) in 20 ml of 20% hydrobromic acid in glacial acetic acid and stir the mixture at room temperature for two hours. Add the mixture dropwise to diethyl ether at 0°-5° to give 1,4-dithia-7-azaspiro[4.4]nonane-8(S)-carboxylic acid methyl ester hydrobromide, a brown solid m.g. 156°-158°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04470972 |
| Source dataset | uspto-grants-1984_09 |
| ORD ID | ord-b1279d3e1379448783e21a71dc1ae1f7 |
| Source note | uspto-grants-1984_09 |